The Mediterranean Palace Hotel Thessaloniki is a part of the Ladadika area, so the surrounding streets are full of live music venues, restaurants, bars, and clubs. The Mediterranean Palace Hotel Thessaloniki is about 10 minutes from the main rail station, and the international airport is about 30 minutes away by car.

The 118 rooms at the Mediterranean Palace Hotel Thessaloniki are decorated with red and gold fabrics. Rooms have soundproofing, Internet access, individualized climate control, satellite television, mini bar, radio alarm clock, and bathrooms with hair dryers. Non-smoking and handicapped accessible rooms are also offered.

The Mediterranean Palace Hotel Thessaloniki is a five star property decorated in red and gold. The on site restaurant offers upscale dining, while the house bar lounge has a domed glass ceiling offering views over the bay. The conference rooms are available for business or social events. For relaxation, the property offers an indoor swimming pool and a sauna. Free wireless Internet is provided throughout the property. Private underground parking, staffed with a guard, is offered to guests.